Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015.
Identifieur interne : 000390 ( Main/Exploration ); précédent : 000389; suivant : 000391Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015.
Auteurs : Yeon-Sook Kim ; Abdimadiyeva Aigerim ; Uni Park ; Yuri Kim ; Ji-Young Rhee ; Jae-Phil Choi ; Wan Beom Park ; Sang Won Park ; Yeonjae Kim ; Dong-Gyun Lim ; Kyung-Soo Inn ; Eung-Soo Hwang ; Myung-Sik Choi ; Hyoung-Shik Shin ; Nam-Hyuk ChoSource :
- Emerging infectious diseases [ 1080-6059 ] ; 2019.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps neutralisants (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Femelle, Flambées de maladies, Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Génotype, Histoire du 21ème siècle, Humains, Infections à coronavirus (histoire), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Maladies transmissibles émergentes (histoire), Maladies transmissibles émergentes (immunologie), Maladies transmissibles émergentes (virologie), Maladies transmissibles émergentes (épidémiologie), Mutation, Mâle, Sujet âgé, Tests de neutralisation.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus.
- histoire : Infections à coronavirus, Maladies transmissibles émergentes.
- immunologie : Anticorps neutralisants, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Maladies transmissibles émergentes.
- virologie : Infections à coronavirus, Maladies transmissibles émergentes.
- épidémiologie : Infections à coronavirus, Maladies transmissibles émergentes.
- Adulte, Adulte d'âge moyen, Femelle, Flambées de maladies, Génotype, Histoire du 21ème siècle, Humains, Mutation, Mâle, Sujet âgé, Tests de neutralisation.
English descriptors
- KwdEn :
- Adult, Aged, Antibodies, Neutralizing (immunology), Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (history), Communicable Diseases, Emerging (immunology), Communicable Diseases, Emerging (virology), Coronavirus Infections (epidemiology), Coronavirus Infections (history), Coronavirus Infections (immunology), Coronavirus Infections (virology), Disease Outbreaks, Female, Genotype, History, 21st Century, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Mutation, Neutralization Tests, Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology).
- MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- chemical , immunology : Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus.
- epidemiology : Communicable Diseases, Emerging, Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- history : Communicable Diseases, Emerging, Coronavirus Infections.
- immunology : Communicable Diseases, Emerging, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- virology : Communicable Diseases, Emerging, Coronavirus Infections.
- Adult, Aged, Disease Outbreaks, Female, Genotype, History, 21st Century, Humans, Male, Middle Aged, Mutation, Neutralization Tests.
Abstract
The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several "superspreading" events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epidemiology. We found sequential emergence of the spike mutations in 2 superspreaders. In vivo virulence of the mutant viruses seems to decline in human patients, as assessed by fever duration in affected persons. In addition, neutralizing activity against these 2 mutant viruses in serum samples from mice immunized with wild-type spike antigen were gradually reduced, suggesting emergence and wide spread of neutralization escapers during the outbreak.
DOI: 10.3201/eid2506.181722
PubMed: 30900977
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000600
- to stream PubMed, to step Curation: 000600
- to stream PubMed, to step Checkpoint: 000387
- to stream Ncbi, to step Merge: 002156
- to stream Ncbi, to step Curation: 002156
- to stream Ncbi, to step Checkpoint: 002156
- to stream Main, to step Merge: 000393
- to stream Main, to step Curation: 000390
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015.</title>
<author><name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name>
</author>
<author><name sortKey="Aigerim, Abdimadiyeva" sort="Aigerim, Abdimadiyeva" uniqKey="Aigerim A" first="Abdimadiyeva" last="Aigerim">Abdimadiyeva Aigerim</name>
</author>
<author><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name>
</author>
<author><name sortKey="Kim, Yuri" sort="Kim, Yuri" uniqKey="Kim Y" first="Yuri" last="Kim">Yuri Kim</name>
</author>
<author><name sortKey="Rhee, Ji Young" sort="Rhee, Ji Young" uniqKey="Rhee J" first="Ji-Young" last="Rhee">Ji-Young Rhee</name>
</author>
<author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name>
</author>
<author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
</author>
<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
</author>
<author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name>
</author>
<author><name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name>
</author>
<author><name sortKey="Inn, Kyung Soo" sort="Inn, Kyung Soo" uniqKey="Inn K" first="Kyung-Soo" last="Inn">Kyung-Soo Inn</name>
</author>
<author><name sortKey="Hwang, Eung Soo" sort="Hwang, Eung Soo" uniqKey="Hwang E" first="Eung-Soo" last="Hwang">Eung-Soo Hwang</name>
</author>
<author><name sortKey="Choi, Myung Sik" sort="Choi, Myung Sik" uniqKey="Choi M" first="Myung-Sik" last="Choi">Myung-Sik Choi</name>
</author>
<author><name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name>
</author>
<author><name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:30900977</idno>
<idno type="pmid">30900977</idno>
<idno type="doi">10.3201/eid2506.181722</idno>
<idno type="wicri:Area/PubMed/Corpus">000600</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000600</idno>
<idno type="wicri:Area/PubMed/Curation">000600</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000600</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000387</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000387</idno>
<idno type="wicri:Area/Ncbi/Merge">002156</idno>
<idno type="wicri:Area/Ncbi/Curation">002156</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002156</idno>
<idno type="wicri:Area/Main/Merge">000393</idno>
<idno type="wicri:Area/Main/Curation">000390</idno>
<idno type="wicri:Area/Main/Exploration">000390</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015.</title>
<author><name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name>
</author>
<author><name sortKey="Aigerim, Abdimadiyeva" sort="Aigerim, Abdimadiyeva" uniqKey="Aigerim A" first="Abdimadiyeva" last="Aigerim">Abdimadiyeva Aigerim</name>
</author>
<author><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name>
</author>
<author><name sortKey="Kim, Yuri" sort="Kim, Yuri" uniqKey="Kim Y" first="Yuri" last="Kim">Yuri Kim</name>
</author>
<author><name sortKey="Rhee, Ji Young" sort="Rhee, Ji Young" uniqKey="Rhee J" first="Ji-Young" last="Rhee">Ji-Young Rhee</name>
</author>
<author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name>
</author>
<author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
</author>
<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
</author>
<author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name>
</author>
<author><name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name>
</author>
<author><name sortKey="Inn, Kyung Soo" sort="Inn, Kyung Soo" uniqKey="Inn K" first="Kyung-Soo" last="Inn">Kyung-Soo Inn</name>
</author>
<author><name sortKey="Hwang, Eung Soo" sort="Hwang, Eung Soo" uniqKey="Hwang E" first="Eung-Soo" last="Hwang">Eung-Soo Hwang</name>
</author>
<author><name sortKey="Choi, Myung Sik" sort="Choi, Myung Sik" uniqKey="Choi M" first="Myung-Sik" last="Choi">Myung-Sik Choi</name>
</author>
<author><name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name>
</author>
<author><name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name>
</author>
</analytic>
<series><title level="j">Emerging infectious diseases</title>
<idno type="eISSN">1080-6059</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Communicable Diseases, Emerging (epidemiology)</term>
<term>Communicable Diseases, Emerging (history)</term>
<term>Communicable Diseases, Emerging (immunology)</term>
<term>Communicable Diseases, Emerging (virology)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (history)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Genotype</term>
<term>History, 21st Century</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Mutation</term>
<term>Neutralization Tests</term>
<term>Spike Glycoprotein, Coronavirus (genetics)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Glycoprotéine de spicule des coronavirus (génétique)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Génotype</term>
<term>Histoire du 21ème siècle</term>
<term>Humains</term>
<term>Infections à coronavirus (histoire)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Maladies transmissibles émergentes (histoire)</term>
<term>Maladies transmissibles émergentes (immunologie)</term>
<term>Maladies transmissibles émergentes (virologie)</term>
<term>Maladies transmissibles émergentes (épidémiologie)</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Tests de neutralisation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
</keywords>
<keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps neutralisants</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Coronavirus Infections</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Genotype</term>
<term>History, 21st Century</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Neutralization Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Génotype</term>
<term>Histoire du 21ème siècle</term>
<term>Humains</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Tests de neutralisation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several "superspreading" events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epidemiology. We found sequential emergence of the spike mutations in 2 superspreaders. In vivo virulence of the mutant viruses seems to decline in human patients, as assessed by fever duration in affected persons. In addition, neutralizing activity against these 2 mutant viruses in serum samples from mice immunized with wild-type spike antigen were gradually reduced, suggesting emergence and wide spread of neutralization escapers during the outbreak.</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Aigerim, Abdimadiyeva" sort="Aigerim, Abdimadiyeva" uniqKey="Aigerim A" first="Abdimadiyeva" last="Aigerim">Abdimadiyeva Aigerim</name>
<name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name>
<name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name>
<name sortKey="Choi, Myung Sik" sort="Choi, Myung Sik" uniqKey="Choi M" first="Myung-Sik" last="Choi">Myung-Sik Choi</name>
<name sortKey="Hwang, Eung Soo" sort="Hwang, Eung Soo" uniqKey="Hwang E" first="Eung-Soo" last="Hwang">Eung-Soo Hwang</name>
<name sortKey="Inn, Kyung Soo" sort="Inn, Kyung Soo" uniqKey="Inn K" first="Kyung-Soo" last="Inn">Kyung-Soo Inn</name>
<name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name>
<name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name>
<name sortKey="Kim, Yuri" sort="Kim, Yuri" uniqKey="Kim Y" first="Yuri" last="Kim">Yuri Kim</name>
<name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name>
<name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
<name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name>
<name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
<name sortKey="Rhee, Ji Young" sort="Rhee, Ji Young" uniqKey="Rhee J" first="Ji-Young" last="Rhee">Ji-Young Rhee</name>
<name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000390 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000390 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:30900977 |texte= Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30900977" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
This area was generated with Dilib version V0.6.33. |